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AOD9604 had no significant effect in the 3-KO mice

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The incorporation of a solid implant can cause a mechanical mismatch between the implant and the adjacent vertebrae, which can result in hypermobility and the onset of IVDD in the adjacent discs [121]

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Specific concepts that we believe may be particularly noteworthy include: (1) Misfolding of innate CNS proteins, which then leads to their aggregation into potentially toxic oligomers or amyloids, leading to a toxic gain-of-function via numerous mechanisms including membrane disruption (Kandel et al., 2017

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